The Kaiser Permanente (KP) Research Bank is the second largest biobank in the US. It provides an exceptional opportunity to enable research studies related to the prevention, diagnosis and treatment of disease. KP makes this core resource—including de-identified medical record information, a health survey and biospecimens—available to scientists who apply to use the information for genetic, epidemiological, and other scientific research.
KP is unique in that it is
- population-based, including up to 20-50% of each regional area’s insured population;
- large, consisting of over 11.6 million members; and
- has a well-characterized population, with more than 12 years of electronic medical records.
The KP Research Bank is structured both technically and operationally to provide the widest possible value to the genomics and translational research community. The opportunities for collaborative research are unparalleled.
KPRB’s mission is to create a core resource with high quality biospecimen and data collection to enable research in all areas with an emphasis on genomics and translational research with the goal of advancing knowledge for the prevention, diagnosis, treatment and management of disease that benefits our members and the community at large.
The goals of KPRB are to:
- Establish a resource for investigators both at Kaiser Permanente and external institutions to advance knowledge and understanding of factors involved in human health and disease.
- Enroll 500,000 volunteers.
- Conduct research in strict compliance with all legal requirements and ethical best practices.
- Protect the security and privacy of individuals who contribute data and biospecimens to the KPRB resource in accordance with all applicable legal safeguards.
Description of Our Collections
The KP Research Bank includes members aged 18 and over, from all KP regions, who volunteered to participate in the program.
*As of January 2019
The KP Research Bank is currently enrolling, consenting, and collecting blood specimens and other data on adult KP members aged 18 years and older who volunteer. Recruitment is done using e- mail, U.S. mail and in person communications at KP facilities.
To enable the broadest possible collaborative opportunities for the KP Research Bank, we collect biologic samples with a consent that specifies use in future research, and possible sharing of data with researchers outside KP. We collect whole blood through standard venipuncture at any KP clinical laboratory. Primary sample types stored are whole blood, DNA and serum.
Although a large general cohort will have many prevalent cases of common and rare diseases that are useful for case- control studies, the need for very large sample sizes is critical to determine their association with a trait or disease. The recent advent of lower cost and high throughput technologies such as next generation sequencing — such as with large gene panels, exome and whole genome sequencing — can identify rare variants.
Some participants in the KPRB general cohort were initially enrolled through the Research Program on Genes, Environment and Health (RPGEH) in Northern and Southern California. These participants provided a saliva sample in a whole-saliva collection kit (OrageneTM DNA collection kit, DNA Genotek, Inc., Ottawa, Ontario, Canada). In 2011, RPGEH transitioned from collection of saliva to the collection of blood specimens from participants. 103,000 of these subjects have available Affymetrics Axiom array data, a subset of which is available on the dbGaP website here.
Exposures during the prenatal period have lasting effects on maternal and child health outcomes. To better understand the effects of the in utero environment on women’s and children’s short- and long-term health, we have developed a large representative pregnancy cohort with comprehensive information on a broad range of environmental influences and the ability to link to prenatal, child and maternal health outcomes. The Kaiser Permanente Research Bank pregnancy cohort was established in 2010 to create a resource for conducting research to better understand factors influencing women’s and children’s health. Based in Kaiser Permanente’s Northern California region, with recruitment integrated into routine prenatal care, the KPRB pregnancy cohort currently contains approximately 25,000 unique pregnancies linked to EHR and survey data. The cohort represents the racial and ethnic diversity and pregnancy outcomes of female members in Kaiser Permanente Northern California.
An estimated 15.5 million cancer survivors live in the United States, and that number is expected to grow to over 20 million by 2026 (www.cancercontrol.cancer.gov/ocs). The need to identify ways to reduce the burden of cancer, through improved and targeted therapies, and symptom control remains an urgent element of the nation’s health research agenda. The purpose of the Cancer Cohort is to facilitate high-impact, population research focused on understanding the contribution of genetics and life-style factors in improving cancer treatment and outcomes, reducing co-morbidities, and maximizing quality of life. We plan to enroll 30,000 adult Kaiser Permanente members with newly diagnosed cancer using a rapid case ascertainment system that identifies patients within days of their diagnosis.
Demographic and clinical data on cohort members
2007-present: A comprehensive lifestyle and behavior survey is conducted at the time of consent to participation in the General Cohort, Cancer Cohort, and Pregnancy Cohort. Variables include self- and family history of the occurrence of about 35 conditions and diseases; behavioral factors, including diet, physical activity, smoking, and alcohol consumption; reproductive history for women; and urinary and reproductive health for men. This survey captures data not readily found in the medical record and will provide important information that can be associated with the molecular and biomarker information collected via the samples.
Data from electronic medical records and other health plan databases are also available for cohort members. Databases are standardized across the KP regions and include enrollment, demographics, procedures, diagnoses, medical encounters, pharmacy, vital signs, and census variables.
Approved studies may use the clinical and/or survey data with or without the biologic specimens.
The Research Biorepository occupies over 5,000 square feet in Berkeley, California and contains state-of-the-art equipment. The equipment includes an ABF 500 automated blood fractionation robot unit, an RTS A4 temperature and humidity controlled robotic ambient storage unit for storing DNA using Biomatrica DNAstable storage medium, a walk-in -80° C freezer with 2,552 cubic feet of usable storage for approximately 5,000,000 1ml storage tubes, and two MVE1894R-190 liquid nitrogen storage tanks. The freezers have 24-7 alarms and monitoring with redundant back-up support of uninterrupted power source (UPS), freestanding diesel power generator, and liquid nitrogen. In addition, the laboratory contains one upright -80° C freezer, two -20° C freezers, two refrigerators and other routine laboratory equipment (e.g., centrifuges, liquid handlers (Beckman Coulter and Tecan), DI water, biological hoods, capper/decapper units, etc.)
The Biorepository laboratory is capable of high-throughput processing of new specimens and DNA extraction, normalization and plating with this equipment. A custom developed Laboratory Information Management System (LIMS) tracks specimens at each step. The Berkeley facility maintains an ISO-certification for continuous improvement as a world-class storage facility. It is accredited by the College of American Pathologists (CAP) in recognition for its commitment to continuous adherence to industry best practices for processing, long term storage, retrieval, and distribution of specimens.
About the KP Research Bank
Elizabeth McGlynn, PhD–Interim Executive Director
Senior Administrative Leadership
Sarah Rowell, MPH – Administrative Director, Program Office
Alan Bauck, MBA – Data Coordination Core, Lead
Alex Lituev, MD – Biorepository Lead
Anand Sethuraman, PhD— Genomics Engineer
Andrew Bradlyn, PhD – KP Georgia Scientific Lead
Heather Feigelson PhD, MPH – KP Colorado Scientific Lead and Cancer Cohort Lead
Stacey Honda, MD – KP Hawaii Scientific Lead
Michael Horberg MD, MAS, FACP, FIDSA – KP Mid-Atlantic States Scientific Lead
James Ralston, MD, MPH — KP Washington Scientific Lead
Cathy Schaefer, PhD – KP Northern California Scientific Lead and Scientific Director of Data Coordination Core
Sheila Weinmann, PhD, MPH – KP Northwest Scientific Lead
Deborah Young, PhD – KP Southern California Scientific Lead
Lisa Croen, PhD – Pregnancy Cohort Lead
Andrea Burnett-Hartman, PhD, MPH — Investigator, KP Colorado
Sarah Madrid, MA— Community Engagement and Outreach Scientific Lead, KP Colorado
Aldwin Carino, MS, CLS — Quality and Compliance Lead, ISO Management Rep, Program Office
Terrence Chinn, MS – Project Manager Data Coordination Core, KP Northern California
Matthew Dahlquist, MBA— Financial Analyst, Program Office
Robyn Gerdes, MPH— Lead Project Manager, Program Office
Trine Jeppesen – Contact Center Lead, Program Office
Marianne Sadler, MPH – LIMS and Systems Lead, Program Office
Inga Wagar – Access Administrator, Program Office
Shauna Scott, MPH, CHES – Operations Lead, KP Colorado
Brandi Robinson, MPH – Operations Lead, KP Georgia
Cyndee Yonehara, MPH – Operations Lead, KP Hawaii
Cabell Jonas, PhD – Operations Lead, KP Mid-Atlantic States
Elaine Chung, MPH – Operations Lead, KP Northern California
Lucy Fulton – Operations Lead, KP Northwest
Galina Inzhakova, MPH – Operations Lead, KP Southern California
Tricia Buscio, RN, MHA, MS Law — Operations Lead, KP Washington
Aaron Scrol, MS — Operations Lead, KP Washington
KP Research Bank Advisors
Scientific Advisory Board (SAB)
The Scientific Advisory Board provides scientific leadership and guidance to the research team. For more information, please contact us.
Joan Bailey-Wilson, PhD
Head, Statistical Genetics Section
Co-Branch Chief, Computational and Statistical Genomics Branch
National Human Genome Research Institute
Alpa Patel, PhD
Strategic Director, CPS-3
American Cancer Society
Brenda Eskenazi, PhD
Maxwell Professor of Maternal and Child Health and Epidemiology
Chair, Community Health and Human Development
School of Public Health, Division of Epidemiology
University of California, Berkeley
Sandra Soo-Jin Lee, PhD
Chief, Division of Ethics
Department of Medical Humanities and Ethics (MHE)
Vagelos College of Physicians & Surgeons
Daniel Schaid, PhD
Professor of Biostatistics
Department of Health Sciences Research
Marc Weisskopf, PhD, ScD
Departments of Environmental Health and Epidemiology
Harvard School of Public Health
Muin J. Khoury, MD, PhD
Director, Office of Public Health Genomics
Centers for Disease Control and Prevention
Bioethics Advisory Board (BAB)
The Bioethics Advisory Board provides leadership regarding bioethical issues and best practices in issues of ethics and governance. For more information please contact us.
Eric Garcia, MS
National Research Compliance Officer and Director of the National Compliance in Research Support Program (N-CRSP)
Kaiser Foundation Research Institute (KFRI)
Hank Greely, JD
Director, Center for Law and the Biosciences
Stanford Law School
Malia Fullerton, DPhil
Director, Institute for Public Health Genetics
University of Washington School of Public Health
Barbara Koenig, PhD
Professor, Institute for Health and Aging
University of California, San Francisco
Sandra Soo-Jin Lee, PhD
Chief, Division of Ethics
Department of Medical Humanities and Ethics (MHE)
Vagelos College of Physicians & Surgeons
Osagie Obasogie, JD, PhD
Haas Distinguished Chair and Professor of Bioethics
Joint Medical Program
Division of Community Health Sciences
University of California, Berkeley
Maile Taualii, PhD, MPH
University of Hawaii
Community Advisory Boards (CAB)
Three CABs — two regional and one national — represent the voice of the communities Kaiser Permanente serves. The CABs provide a diversity of input on a wide range of issues related to the KP Research Bank’s role in public health.
Within all regions, KP members and non-members are represented, as are the voices of advocacy, environmental and community-based health groups, community leaders, social safety-net providers, labor and public health organizations, academic institutions, and others.
For more information about the Community Advisory boards, please contact us.
National Community Advisory Board
Steven Prieto, Retired, US Department of State
Brian B. Clarke
Selena L. Dunham, Owner, Classique, LLC
Naomi Iwasaki, Deputy Director, Investing in Place
Hector Gutierrez, Program Officer, First 5 LA
Gerald Greene, Board Member, Prostate Support Group for African-American men, The Men’s Health Committee in partnership with UCSF Helen Diller Family Comprehensive Cancer Center and the Alameda County Public Health Department
Christopher Parker, MBBS, MPH, Director, Population and Global Health, Georgia Health Policy Center, Georgia State University
Mid-Atlantic States Community Advisory Board
Iris Molotsky, MA, Director of Membership and Public Relations, American Association of University Professors
Donney John, PharmD, Executive Director, NOVA Scripts Central
Alain Noriega, MBA, Pastor, Community Church
Elizabeth Noriega, Full time mother and student
Carolyn A. Taylor, RNC, MSN, MBA, PhD, Corporate Operations Officer, Taylor-Oden Enterprises
Les Taylor, PhD, MBA, President/CEO, Taylor-Oden Enterprises
Jessica M. Xavier, MPH, Independent Consultant
Paula Davis, MPH, CHES, Community Advocate, Greater Landover Knolls
Southern California Community Advisory Board
Monica Alvarado, MS, CGC, Regional Genetic Services Administrator, Southern California Permanente Medical Group
Refugio Mata, California Program Director, Resource Media
Scott Chan, Program Director, API Forward Movement
Tiffany McDaniel, West Coast Organizing Director, National Foster Youth Institute
Rocco C. Cheng, PhD, Principal Consultant, Drikung Rinchen Choling- Buddhist Center & Rocco Cheng and Associates
Alejandro Aldana, Health Services and Behavioral Research Assistant, Children’s Hospital Los Angeles
Naomi Iwasaki, Deputy Director, Investing in Place
Hector Gutierrez, Program Officer, First 5 Los Angeles
Demi Espinoza, Regional Policy Manager, Safe Routes to School National Partnership
Institutional Review Board (IRB)
Similar to all research institutions, the KP Research Bank is required to have an Institutional Review Board (IRB). This governing body of physicians, scientists, and community representatives reviews and approves every study before it begins.
The goal of this Board is to minimize any risk to participants by making sure that the KP Research Bank, as well as collaborating organizations and research scientists, follow federal research regulations, guidelines, and ethical principles.
Researcher Application Process
Access Review Committee and Review Criteria
The KP Research Bank Access Review Committee (ARC) reviews each research proposal.
The KP Research Bank strives for transparency in the review process. The table found here outlines the review criteria used to assess KP Research Bank pre-applications and applications. If you have questions about the review criteria or process, complete the form below.
Applications are subject to two stages of review: Pre-application review and application review.
- Pre-applications may be submitted at any time.
- Annual submission deadlines for applications are February 15th, April 15th, June 15th, August 15th, October 15th, and December 15th Applications will be reviewed by the ARC in the month following the deadline.
If you are interesting in conducting research with the KP Research Bank, but you have more questions, fill out and submit the form below.
To submit a pre-application, please click on Apply to Use Resource to register for the KP Research Bank Access Portal. After doing so, you will receive a verification email in 1-2 business days with instructions for submitting your pre-application. If you have any questions, please contact the Access Administrator using the form below. For reference only, please see the pre-application below.
If your pre-application is approved, you will receive an email notification inviting you to submit an application through the KP Research Bank Access Portal.
- Pre-applications will be reviewed by the ARC within 2-4 weeks of submission, depending on whether assistance is required to identify a KP collaborator.
- If the pre-application is approved, the Access Administrator will notify and invite the investigator via email to submit an application.
The purpose of the pre-application is to:
- Outline the proposed research project, including requested biospecimens and/or data (1 page limit)
- Provide a brief lay summary of the proposed research project that can be understood by members of the public (200 word limit)
- Outline the credentials of the applicant
- Request KP collaborators if not already identified
Once your pre-application has been approved, you will be invited to submit an application through the KP Research Bank Access Portal. For reference only, please see the Application below.
News and Updates
Select publications using the KP Research Bank resource, or prior KP biobanking resources including the Research Program on Genes, Environment, and Health.
- Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, Kvale MN, Banda Y, Tolman NG, Williams PA, Schaefer C, Melles RB, Risch N, John SWM, Nair KS, Jorgenson E. A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. Nat Commun. 2018 Jun 11;9(1):2278. doi: 10.1038/s41467-018-04555-4. PubMed PMID: 29891935; PubMed Central PMCID: PMC5995837.
- Kim SK, Ioannidis JPA, Ahmed MA, Avins AL, Kleimeyer JP, Fredericson M, Dragoo JL. Two Genetic Variants Associated with Plantar Fascial Disorders. Int J Sports Med. 2018 Apr;39(4):314-321. doi: 10.1055/s-0044-100280. Epub 2018 Mar 13. PubMed PMID: 29534260.
- Hoffmann TJ, Theusch E, Haldar T, Ranatunga DK, Jorgenson E, Medina MW, Kvale MN, Kwok PY, Schaefer C, Krauss RM, Iribarren C, Risch N. A large electronic-health-record-based genome-wide study of serum lipids. Nat Genet. 2018 Mar;50(3):401-413. doi: 10.1038/s41588-018-0064-5. Epub 2018 Mar 5. PubMed PMID: 29507422; PubMed Central PMCID: PMC5942247.
- Chen HY, Dufresne L, Burr H, Ambikkumar A, Yasui N, Luk K, Ranatunga DK, Whitmer RA, Lathrop M, Engert JC, Thanassoulis G. Association of LPA Variants With Aortic Stenosis: A Large-Scale Study Using Diagnostic and Procedural Codes From Electronic Health Records. JAMA Cardiol. 2018 Jan 1;3(1):18-23. doi: 10.1001/jamacardio.2017.4266. PubMed PMID: 29128868.
- Choquet H, Thai KK, Yin J, Hoffmann TJ, Kvale MN, Banda Y, Schaefer C, Risch N, Nair KS, Melles R, Jorgenson E. A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. Nat Commun. 2017 Dec 13;8(1):2108. doi: 10.1038/s41467-017-01913-6. PubMed PMID: 29235454; PubMed Central PMCID: PMC5727399.
- Roos TR, Roos AK, Avins AL, Ahmed MA, Kleimeyer JP, Fredericson M, Ioannidis JPA, Dragoo JL, Kim SK. Genome-wide association study identifies a locus associated with rotator cuff injury. PLoS One. 2017 Dec 11;12(12):e0189317. doi: 10.1371/journal.pone.0189317. eCollection 2017. PubMed PMID: 29228018; PubMed Central PMCID: PMC5724859.
- Kim SK, Ahmed MA, Avins AL, Ioannidis JPA. A Genetic Marker Associated with De Quervain’s Tenosynovitis. Int J Sports Med. 2017 Nov;38(12):942-948. doi: 10.1055/s-0043-116669. Epub 2017 Oct 6. PubMed PMID: 28985641.
- Kim SK, Kleimeyer JP, Ahmed MA, Avins AL, Fredericson M, Dragoo JL, Ioannidis JPA. Two genetic loci associated with ankle injury. PLoS One. 2017 Sep 28;12(9):e0185355. doi: 10.1371/journal.pone.0185355. eCollection 2017. PubMed PMID: 28957384; PubMed Central PMCID: PMC5619760.
- Kim S, Kleimeyer JP, Ahmed MA, Avins AL, Fredericson M, Dragoo JL, Ioannidis JPA. A Genetic Marker Associated with Shoulder Dislocation. Int J Sports Med. 2017 May 18. doi: 10.1055/s-0043-106190. [Epub ahead of print] German. PubMed PMID: 28521375.
- Jorgenson E, Thai KK, Hoffmann TJ, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Mertens J, Weisner C, Choquet H. Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. Mol Psychiatry. 2017 May 9. doi: 10.1038/mp.2017.101. [Epub ahead of print] PubMed PMID: 28485404.
- Roos AK, Avins AL, Ahmed MA, Kleimeyer JP, Roos TR, Fredericson M, Ioannidis JPA, Dragoo JL, Kim S. Two Genetic Loci associated with Medial Collateral Ligament Injury. Int J Sports Med. 2017 May 8. doi: 10.1055/s-0043-104853. [Epub ahead of print] PubMed PMID: 28482362.
- Gianfrancesco MA, Stridh P, Rhead B, Shao X, Xu E, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Bäärnhielm M, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Metayer C, Schaefer C, Barcellos LF, Waubant E; Network of Pediatric Multiple Sclerosis Centers. Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS. Neurology. 2017 Apr 25;88(17):1623-1629. doi: 10.1212/WNL.0000000000003849. Epub 2017 Mar 29. PubMed PMID: 28356466; PubMed Central PMCID: PMC5405763.
- Kim SK, Roos TR, Roos AK, Kleimeyer JP, Ahmed MA, Goodlin GT, Fredericson M, Ioannidis JP, Avins AL, Dragoo JL. Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy. PLoS One. 2017 Mar 30;12(3):e0170422. doi: 10.1371/journal.pone.0170422. eCollection 2017. PubMed PMID: 28358823; PubMed Central PMCID: PMC5373512.
- Gianfrancesco MA, Glymour MM, Walter S, Rhead B, Shao X, Shen L, Quach H, Hubbard A, Jónsdóttir I, Stefánsson K, Strid P, Hillert J, Hedström A, Olsson T, Kockum I, Schaefer C, Alfredsson L, Barcellos LF. Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility. Am J Epidemiol. 2017 Feb 1;185(3):162-171. doi: 10.1093/aje/kww120. PubMed PMID: 28073764; PubMed Central PMCID: PMC5391720.
- Hoffmann TJ, Passarelli MN, Graff RE, Emami NC, Sakoda LC, Jorgenson E, Habel LA, Shan J, Ranatunga DK, Quesenberry CP, Chao CR, Ghai NR, Aaronson D, Presti J, Nordström T, Wang Z, Berndt SI, Chanock SJ, Mosley JD, Klein RJ, Middha M, Lilja H, Melander O, Kvale MN, Kwok PY, Schaefer C, Risch N, Van Den Eeden SK, Witte JS. Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer. Nat Commun. 2017 Jan 31;8:14248. doi: 10.1038/ncomms14248. PubMed PMID: 28139693; PubMed Central PMCID: PMC5290311.
- Hoffmann TJ, Ehret GB, Nandakumar P, Ranatunga D, Schaefer C, Kwok PY, Iribarren C, Chakravarti A, Risch N. Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. Nat Genet. 2017 Jan;49(1):54-64. doi: 10.1038/ng.3715. PubMed PMID: 27841878.
- Brant SR, Okou DT, Simpson CL, Cutler DJ, Haritunians T, Bradfield JP, Chopra P, Prince J, Begum F, Kumar A, Huang C, Venkateswaran S, Datta LW, Wei Z, Thomas K, Herrinton LJ, Klapproth JA, Quiros AJ, Seminerio J, Liu Z, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Dryden GW, Hanson JS, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kirschner BS, Kuemmerle JF, Kwon JH, Lazarev M, Li E, Mack D, Mannon P, Moulton DE, Newberry RD, Osuntokun BO, Patel AS, Saeed SA, Targan SR, Valentine JF, Wang MH, Zonca M, Rioux JD, Duerr RH, Silverberg MS, Cho JH, Hakonarson H, Zwick ME, McGovern DP, Kugathasan S. Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease. Gastroenterology. 2017 Jan;152(1):206-217.e2. doi: 10.1053/j.gastro.2016.09.032. PubMed PMID: 27693347; PubMed Central PMCID: PMC5164948.
- Kvale MN, Hesselson S, Hoffmann TJ, Cao Y, Chan D, Connell S, Croen LA, Dispensa BP, Eshragh J, Finn A, Gollub J, Iribarren C, Jorgenson E, Kushi LH, Lao R, Lu Y, Ludwig D, Mathauda GK, McGuire WB, Mei G, Miles S, Mittman M, Patil M, Quesenberry CP Jr, Ranatunga D, Rowell S, Sadler M, Sakoda LC, Shapero M, Shen L, Shenoy T, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Wan E, Webster T, Whitmer RA, Wong S, Zau C, Zhan Y, Schaefer C, Kwok PY, Risch N. Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. 2015 Aug;200(4):1051-60. doi: 10.1534/genetics.115.178905. PubMed PMID: 26092718; PubMed Central PMCID: PMC4574249.
- Banda Y, Kvale MN, Hoffmann TJ, Hesselson SE, Ranatunga D, Tang H, Sabatti C, Croen LA, Dispensa BP, Henderson M, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Olberg D, Quesenberry CP Jr, Rowell S, Sadler M, Sakoda LC, Sciortino S, Shen L, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Whitmer RA, Kwok PY, Schaefer C, Risch N. Characterizing race/ethnicity and genetic ancestry for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. Genetics. 2015 Aug;200(4):1285-95. doi: 10.1534/genetics.115.178616. PubMed PMID: 26092716; PubMed Central PMCID: PMC4574246.
- Lapham K, Kvale MN, Lin J, Connell S, Croen LA, Dispensa BP, Fang L, Hesselson S, Hoffmann TJ, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Matsuguchi T, McGuire WB, Miles S, Quesenberry CP Jr, Rowell S, Sadler M, Sakoda LC, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Whitmer RA, Kwok PY, Risch N, Schaefer C, Blackburn EH. Automated assay of telomere length measurement and informatics for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. 2015 Aug;200(4):1061-72. doi: 10.1534/genetics.115.178624. PubMed PMID: 26092717; PubMed Central PMCID: PMC4574243.
- Hoffmann TJ, Zhan Y, Kvale MN, Hesselson SE, Gollub J, Iribarren C, Lu Y, Mei G, Purdy MM, Quesenberry C, Rowell S, Shapero MH, Smethurst D, Somkin CP, Van den Eeden SK, Walter L, Webster T, Whitmer RA, Finn A, Schaefer C, Kwok PY, Risch N. Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm. Genomics. 2011 Dec;98(6):422-30. doi: 10.1016/j.ygeno.2011.08.007. PubMed PMID: 21903159; PubMed Central PMCID: PMC3502750.
- Hoffmann TJ, Kvale MN, Hesselson SE, Zhan Y, Aquino C, Cao Y, Cawley S, Chung E, Connell S, Eshragh J, Ewing M, Gollub J, Henderson M, Hubbell E, Iribarren C, Kaufman J, Lao RZ, Lu Y, Ludwig D, Mathauda GK, McGuire W, Mei G, Miles S, Purdy MM, Quesenberry C, Ranatunga D, Rowell S, Sadler M, Shapero MH, Shen L, ShenoyTR, Smethurst D, Van den Eeden SK, Walter L, Wan E, Wearley R, Webster T, Wen CC, Weng L, Whitmer RA, Williams A, Wong SC, Zau C, Finn A, Schaefer C, Kwok PY, Risch N. Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array. Genomics. 2011 Aug;98(2):79-89. doi: 10.1016/j.ygeno.2011.04.005. PubMed PMID: 21565264; PubMed Central PMCID: PMC3146553.