For Researchers

The Kaiser Permanente (KP) Research Bank is a nationwide biobank that enables research studies related to the prevention, diagnosis and treatment of disease. KP makes this core resource—including de-identified medical record information, a health survey and biospecimens—available to scientists who apply to use the information for genetic, epidemiological, and other scientific research.

About the KP Research Bank

Administrative Leadership of KP Research Bank

Nazneen Aziz, PhD – Executive Director, Program Office

Sarah Rowell, MPH – Administrative Director, Program Office

Alan Bauck, MBA – Data Coordination Core, Lead

Julie Harris-Wai, PhD, MPH – Translational Research Center, Lead

Scientific Leadership of the KP Research Bank

Nazneen Aziz, PhD – Executive Director, Program Office

Heather Feigelson PhD, MPH – KP Colorado Scientific Lead and Cancer Cohort Lead

Andrew Bradlyn, PhD – KP Georgia Scientific Lead

Stacey Honda, MD – KP Hawaii Scientific Lead

Michael Horberg MD, MAS, FACP, FIDSA – KP Mid-Atlantic States Scientific Lead

Cathy Schaefer, PhD – KP Northern California Scientific Lead and Scientific Director of Data Coordination Core

Sheila Weinmann, PhD, MPH – KP Northwest Scientific Lead

Deborah Young, PhD – KP Southern California Scientific Lead

Lisa Croen, PhD – Pregnancy Cohort Lead

Staff of the KP Research Bank

Trine Jeppeson – Contact Center Lead, Program Office

Marianne Sadler, MPH – LIMS and Systems Lead, ISO management rep, Program Office

Inga Wagar – Access Administrator, Program Office

Susan Woo, Laboratory Practice Specialist – Program Office

Michelle Wrenn, MPH – Operations Lead, KP Colorado

Brandi Robinson, MPH – Operations Lead, KP Georgia

Cyndee Yonehara, MPH – Operations Lead, KP Hawaii

Cabell Jonas, PhD – Operations Lead – KP MidAtlantic States

Elaine Chung, MPH – Operations Lead KP Northern California

Kristin Muessig, MPH – Operations Lead, KP Northwest

Miki Nguyen, MPH – Operations Lead – KP Southern California

Terrence Chinn, MPH – Project Manager Data Coordination Core, KP Northern California

Funding

Kaiser Permanente has invested core funding for the development of the KP Research Bank. Building the KP Research Bank is a part of the KP mission to improve health for KP members and the communities KP is serving. Conducting research, developing and disseminating evidence-based knowledge is an integral part of the belief in the Total Health of individuals and communities.

Research Areas and Resource Descriptions

The KP Research Bank is a core resource designed to support research in a variety of health-related areas. The KP Research Bank includes members aged 18 and over, from all seven KP regions, who volunteered to participate in the program.

Specific Research Areas

Within the KP Research Bank program, volunteers with certain health conditions offer an opportunity for targeted research in those areas:

Cancer

KP members aged 18 and over from several KP regions have been identified using a rapid case ascertainment process. These volunteers completed a survey addendum with cancer-related questions.

Pregnancy

KP members aged 18 and over from the KP Northern California region have volunteered to participate in the program while pregnant. These volunteers contributed a first and second trimester blood draw.

Resource Descriptions

The KP Research Bank includes members aged 18 and over, from all seven KP regions, who volunteered to participate in the program.

0
Enrolled
(consent and sample)
0
Enrolled + Survey
0
Saliva
0
Serum
0
Blood
0
DNA
0
Plasma
0
Buffy Coat

*As of February 2017

Researcher Application Process

Access Review Committee and Review Criteria

The KP Research Bank Access Review Committee (ARC) reviews each research proposal.

The KP Research Bank strives for transparency in the review process. The table found here outlines the review criteria used to assess KP Research Bank pre-applications and applications. If you have questions about the review criteria or process, complete the form below.

Submission Deadlines

Applications are subject to two stages of review: Pre-application review and application review.

  • Pre-applications may be submitted at any time.
  • Annual submission deadlines for applications are February 15th, April 15th, June 15th, August 15th, October 15th, and December 15th Applications will be reviewed by the ARC in the month following the deadline.

If you are interesting in conducting research with the KP Research Bank, but you have more questions, fill out and submit the form below.

Pre-application

To submit your pre-application, please contact our Access Administrator by using the form below.

  • Pre-applications will be reviewed by the ARC within 2-4 weeks of submission, depending on whether assistance is required to identify a KP collaborator.
  • If the pre-application is approved, the Access Administrator will notify and invite the investigator via email to submit an application.

The purpose of the pre-application is to:

  1. Outline the proposed research project, including requested biospecimens and/or data (1 page limit)
  2. Provide a brief lay summary of the proposed research project that can be understood by members of the public (200 word limit)
  3. Outline the credentials of the applicant
  4. Request KP collaborators if not already identified

KP Research Bank Pre-Application and Instructions

Application

Once your pre-application has been approved, you will be invited to submit an application. For reference, please see the Application below.

KP Research Bank Application and Instructions

Contact the Access Administrator

News and Updates

KP Research Bank Advisors

The KP Research Bank seeks advice from other scientific advisors, ethicists, KP members, and the community at large. This ensures that the research programs address the goals and concerns of all stakeholders.

Scientific Advisory Board

The Scientific Advisory Board provides scientific leadership and guidance to the research team. For more information, please contact us.

Joan Bailey-Wilson, PhD
Head, Statistical Genetics Section
Co-Branch Chief, Computational and Statistical Genomics Branch
National Human Genome Research Institute

Rory Collins, PhD
Chief Executive, UK Biobank
Professor of Medicine and Epidemiology
University of Oxford

Alpa Patel, PhD
Strategic Director, CPS-3
American Cancer Society

Brenda Eskenazi, PhD
Maxwell Professor of Maternal and Child Health and Epidemiology
Chair, Community Health and Human Development
School of Public Health, Division of Epidemiology
University of California, Berkeley

Sandra Soo-Jin Lee, PhD
Senior Research Scholar
Center for Biomedical Ethics
Stanford University

Daniel Schaid, PhD
Professor of Biostatistics
Department of Health Sciences Research
Mayo Clinic

Marc Weisskopf, PhD, ScD
Associate Professor
Departments of Environmental Health and Epidemiology
Harvard School of Public Health

Bioethics Advisory Board

The Bioethics Advisory Board provides leadership regarding bioethical issues and best practices in issues of ethics and governance. For more information please contact us.

Eric Garcia, MS
Associate Director, Human Research Protections
Kaiser Foundation Research Institute

Hank Greely, JD
Director, Center for Law and the Biosciences
Stanford Law School

Malia Fullerton, DPhil
Director, Institute for Public Health Genetics
University of Washington School of Public Health

Osagie Obasogie, JD, PhD
Professor of Law
University of California,
Hastings College of the Law

Community Advisory Boards (CAB)

Four CABs — three regional and one national — represent the voice of the communities Kaiser Permanente serves. The CABs provide a diversity of input on a wide range of issues related to the KP Research Bank’s role in public health.

Within all regions, KP members and non-members are represented, as are the voices of advocacy, environmental and community-based health groups, community leaders, social safety-net providers, labor and public health organizations, academic institutions, and others.

For more information about the Community Advisory boards, please contact us.

Institutional Review Board (IRB)

Similar to all research institutions, the KP Research Bank is required to have an Institutional Review Board (IRB). This governing body of physicians, scientists, and community representatives reviews and approves every study before it begins.

The goal of this Board is to minimize any risk to participants by making sure that the KP Research Bank, as well as collaborating organizations and research scientists, follow federal research regulations, guidelines, and ethical principles.

Publications

Select publications using the KP Research Bank resource, or prior KP biobanking resources including the Research Program on Genes, Environment, and Health.

  1. Hoffmann TJ, Keats BJ, Yoshikawa N, Schaefer C, Risch N, Lustig LR. A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records. PLoS Genet. 2016 Oct 20; 12(10):e1006371. doi: 10.1371/journal.pgen.1006371. eCollection 2016. PubMed PMID: 27764096.
  2. Zhou K, Yee SW, Seiser EL, van Leeuwen N, et al. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.  Nat Genet. 2016 Sep;48(9):1055-9. doi: 10.1038/ng.3632. Epub 2016 Aug 8. PubMed PMID: 27500523; PubMed Central PMCID: PMC5007158.
  3. Han E, Abrams B, Sridhar S, Xu F, Hedderson M. Validity of Self-Reported Pre-Pregnancy Weight and Body Mass Index Classification in an Integrated Health Care Delivery System. Paediatr Perinat Epidemiol. 2016 Jul;30(4):314-9. doi: 10.1111/ppe.12286. Epub 2016 Mar 9. PubMed PMID: 26961120.
  4. Sridhar SB, Xu F, Hedderson MM. Trimester-specific gestational weight gain and infant size for gestational age. PLoS One. 2016 Jul 21;11(7):e0159500. doi: 10.1371/journal.pone.0159500. eCollection 2016. PubMed PMID: 27442137; PubMed Central PMCID: PMC4956066.
  5. DeLorenze GN, Nelson CL, Scott WK, Allen AS, Ray GT, Tsai AL, Quesenberry CP Jr, Fowler VG Jr. Polymorphisms in HLA Class II Genes Are Associated With Susceptibility to Staphylococcus aureus Infection in a White Population. J Infect Dis. 2016 Mar 1;213(5):816-23. doi: 10.1093/infdis/jiv483. Epub 2015 Oct 8. PubMed PMID: 26450422; PubMed Central PMCID: PMC4747615.
  6. Shen L, Melles RB, Metlapally R, Barcellos L, Schaefer C, Risch N, Herrinton LJ, Wildsoet C, Jorgenson E. The Association of Refractive Error with Glaucoma in a Multiethnic Population. Ophthalmology. 2016 Jan;123(1):92-101. doi: 10.1016/j.ophtha.2015.07.002. Epub 2015 Aug 8. PubMed PMID: 26260281; PubMed Central PMCID: PMC4695304.
  7. Jorgenson E, Makki N, Shen L, Chen DC, Tian C, Eckalbar WL, Hinds D, Ahituv N, Avins A. A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia. Nat Commun. 2015 Dec 21;6:10130. doi:10.1038/ncomms10130. PubMed PMID: 26686553; PubMed Central PMCID: PMC4703831.
  8. Hoffmann TJ, Van Den Eeden SK, Sakoda LC, Jorgenson E, Habel LA, Graff RE, Passarelli MN, Cario CL, Emami NC, Chao CR, Ghai NR, Shan J, Ranatunga DK, Quesenberry CP, Aaronson D, Presti J, Wang Z, Berndt SI, Chanock SJ, McDonnell SK, French AJ, Schaid DJ, Thibodeau SN, Li Q, Freedman ML, Penney KL, Mucci LA, Haiman CA, Henderson BE, Seminara D, Kvale MN, Kwok PY, Schaefer C, Risch N, Witte JS. A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. Cancer Discov. 2015 Aug;5(8):878-91. doi: 10.1158/2159-8290.CD-15-0315. Epub 2015 Jun 1.PubMed PMID: 26034056; PubMed Central PMCID: PMC4527942.
  9. Kvale MN, Hesselson S, Hoffmann TJ, Cao Y, Chan D, Connell S, Croen LA, Dispensa BP, Eshragh J,  Finn A, Gollub J, Iribarren C, Jorgenson E, Kushi LH, Lao R, Lu Y, Ludwig D, Mathauda GK, McGuire WB, Mei G, Miles S, Mittman M, Patil M, Quesenberry CP Jr, Ranatunga D, Rowell S, Sadler M, Sakoda LC, Shapero M, Shen L, Shenoy T, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Wan E, Webster T, Whitmer RA, Wong S, Zau C, Zhan Y, Schaefer C, Kwok PY, Risch N. Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. 2015 Aug;200(4):1051-60. doi: 10.1534/genetics.115.178905. Epub 2015 Jun 19. PubMed PMID: 26092718; PubMed Central PMCID: PMC4574249.
  10. Banda Y, Kvale MN, Hoffmann TJ, Hesselson SE, Ranatunga D, Tang H, Sabatti C, Croen LA, Dispensa BP, Henderson M, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Olberg D, Quesenberry CP Jr, Rowell S, Sadler M, Sakoda LC, Sciortino S, Shen L, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Whitmer RA, Kwok PY, Schaefer C, Risch N. Characterizing race/ethnicity and genetic ancestry for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. Genetics. 2015 Aug;200(4):1285-95. doi: 10.1534/genetics.115.178616. Epub 2015 Jun 19. PubMed PMID: 26092716; PubMed Central PMCID: PMC4574246.
  11. Lapham K, Kvale MN, Lin J, Connell S, Croen LA, Dispensa BP, Fang L, Hesselson S, Hoffmann TJ, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Matsuguchi T, McGuire WB, Miles S, Quesenberry CP Jr, Rowell S, Sadler M, Sakoda LC, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Whitmer RA, Kwok PY, Risch N, Schaefer C, Blackburn EH. Automated assay of telomere length measurement and informatics for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. 2015 Aug;200(4):1061-72. doi:  10.1534/genetics.115.178624. Epub 2015 Jun 19. PubMed PMID: 26092717; PubMed Central PMCID: PMC4574243.
  12. Shen L, Hoffmann TJ, Melles RB, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Jorgenson E. Differences in the genetic susceptibility to age-related macular degeneration clinical subtypes. Invest Ophthalmol Vis Sci. 2015 Jul 1;56(8):4290-9. doi: 10.1167/iovs.15-16533. PubMed PMID: 26176866; PubMed Central PMCID: PMC4509058.
  13. Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM. Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response. Clin Pharmacol Ther. 2015 May;97(5):518-25. doi: 10.1002/cpt.89. Epub 2015 Apr 6. PubMed PMID:25676789; PubMed Central PMCID: PMC4479153.
  14. Hoffmann TJ, Sakoda LC, Shen L, Jorgenson E, Habel LA, Liu J, Kvale MN, Asgari MM, Banda Y, Corley D, Kushi LH, Quesenberry CP Jr, Schaefer C, Van Den Eeden SK, Risch N, Witte JS. Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort. PLoS Genet. 2015 Jan 28;11(1):e1004930. doi: 10.1371/journal.pgen.1004930. eCollection 2015 Jan. Erratum in: PLoS Genet. 2015 Jun;11(6):e1005362. PLoS Genet. 2015 Apr;11(4):e1005114. PubMed PMID: 25629170; PubMed Central PMCID: PMC4309593.
  15. Wall JD, Tang LF, Zerbe B, Kvale MN, Kwok PY, Schaefer C, Risch N. Estimating genotype error rates from high-coverage next-generation sequence data. Genome Res. 2014 Nov;24(11):1734-9. doi: 10.1101/gr.168393.113. Epub 2014 Oct 10. PubMed PMID: 25304867; PubMed Central PMCID: PMC4216915.
  16. Sridhar SB, Darbinian J, Ehrlich SF, Markman MA, Gunderson EP, Ferrara A, Hedderson MM. Maternal gestational weight gain and offspring risk for childhood overweight or obesity. Am J Obstet Gynecol. 2014 Sep;211(3):259.e1-8. doi: 10.1016/j.ajog.2014.02.030. Epub 2014 Apr 13. PubMed PMID: 24735804.
  17. Van Den Eeden SK, Ferrara A, Shan J, Jacobsen SJ, Quinn VP, Haque R, Quesenberry CP. Impact of type 2 diabetes on lower urinary tract symptoms in men: a cohort study. BMC Urol. 2013 Feb 20;13:12. doi: 10.1186/1471-2490-13-12. PubMed PMID: 23421436; PubMed Central PMCID: PMC3605100.
  18. Van Den Eeden SK, Shan J, Jacobsen SJ, Aaronsen D, Haque R, Quinn VP, Quesenberry CP Jr; Urologic Diseases in America Project. Evaluating racial/ethnic disparities in lower urinary tract symptoms in men. J Urol. 2012 Jan;187(1):185-9. doi: 10.1016/j.juro.2011.09.043. Epub 2011 Nov 17. PubMed PMID: 22100004; PubMed Central PMCID: PMC4005424.
  19. Hoffmann TJ, Zhan Y, Kvale MN, Hesselson SE, Gollub J, Iribarren C, Lu Y, Mei G, Purdy MM, Quesenberry C, Rowell S, Shapero MH, Smethurst D, Somkin CP, Van den Eeden SK, Walter L, Webster T, Whitmer RA, Finn A, Schaefer C, Kwok PY, Risch N. Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm. Genomics. 2011 Dec;98(6):422-30. doi: 10.1016/j.ygeno.2011.08.007. Epub 2011 Aug 28. PubMed PMID: 21903159; PubMed Central PMCID: PMC3502750.
  20. Fortier I, Doiron D, Little J, Ferretti V, L’Heureux F, Stolk RP, Knoppers BM, Hudson TJ, Burton PR; International Harmonization Initiative. Is rigorous retrospective harmonization possible? Application of the DataSHaPER approach across 53 large studies. Int J Epidemiol. 2011 Oct;40(5):1314-28. doi: 10.1093/ije/dyr106. Epub 2011 Jul 30. PubMed PMID: 21804097; PubMed Central PMCID: PMC3204208.
  21. Hoffmann TJ, Kvale MN, Hesselson SE, Zhan Y, Aquino C, Cao Y, Cawley S, Chung E, Connell S, Eshragh J, Ewing M, Gollub J, Henderson M, Hubbell E, Iribarren C, Kaufman J, Lao RZ, Lu Y, Ludwig D, Mathauda GK, McGuire W, Mei G, Miles S, Purdy MM, Quesenberry C, Ranatunga D, Rowell S, Sadler M, Shapero MH, Shen L, ShenoyTR, Smethurst D, Van den Eeden SK, Walter L, Wan E, Wearley R, Webster T, Wen CC, Weng L, Whitmer RA, Williams A, Wong SC, Zau C, Finn A, Schaefer C, Kwok PY, Risch N. Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array. Genomics. 2011 Aug;98(2):79-89. doi: 10.1016/j.ygeno.2011.04.005. Epub 2011 Apr 30. PubMed PMID: 21565264; PubMed Central PMCID: PMC3146553.